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Prostate stem cells: the niche and cell markers.

Takao T, Tsujimura A

Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.

Prostate cancer and benign prostatic hyperplasia are common diseases in elderly men worldwide. Identifying the prostate stem cell is an important tool to investigate the mechanism of these prostatic diseases. Although the prostate stem cell has not yet been detected, progress has been made. The 'niche' or place in which the prostate stem cell resides is thought to be located in the proximal region of the murine prostate, near the urethra. Several candidate prostate stem cell markers are currently under investigation. In this review, we summarize the historical approaches and recent evidence regarding the niche and prostate-specific stem cell markers.

Published 2 April 2008 in Int J Urol, 15(4): 289-94.
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